[A+] Report Synthesis of 2,5-dibromo-3-hexylthiophene for bromination (2,5-dibromo 3-hexyl thiophene 합성 레포트)

소개

"Report Synthesis of 2,5-dibromo-3-hexylthiophene for bromination (2,5-dibromo 3-hexyl thiophene 합성 레포트)"에 대한 내용입니다.

목차

1. Introduction
1) Purpose of the Experiment
2) Theoretical Background

2. Method
1)Materials
2) Procedure

3. Result & Discussion

4. Conclusion

본문내용

- Purpose of the Experiment
To synthesize 2,5-dibromo-3-hexylthiophene using NBS reagent for bromination.

- Theoretical Background
1.NBS(N-bromosuccinimide)
NBS is a brominating and oxidizing agent that is used as source for bromine in radical substitution, electrophilic addition, and electrophilic substitution reactions. NBS bromination of the substrate leads to net oxidation products that do not contain bromine after eliminating HBr in the presence of bases.

2.Electrophilic Aromatic Substitution
The reaction of electrophilic aromatics substitution is the substitution of electrophilic (E+) for protons (H+) in aromatic rings. Since functional groups can be introduced directly into aromatic rings, electrophilic aromatic substitution is the most important method for synthesis of substituted aromatic compounds.

3.Mechanism of Bromination of Benzene
Step 1 : Formation of a stronger electrophile.

참고자료

· Wade, L. G., & Simek, J. W. (2017). Organic Chemistry (9th ed.). Glenview, IL: Pearson.
· Clayden, J., Greeves, N., & Warren, S. (2012). Organic Chemistry (2nd ed.). Oxford: Oxford University Press.
· Smith, M. B., & March, J. (2007). March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th ed.). New York: Wiley.
· Ashenhurst, J. (2020, March 02). N-BromoSuccinimide (NBS) as a reagent in organic chemistry. Retrieved April 1, 2021, from https://www.masterorganicchemistry.com/2011/06/10/reagent-friday-nbs-n-bromo-succinimide/
· Ashenhurst, J. (2021, February 04). Electrophilic aromatic substitution: The six key reactions. Retrieved April 01, 2021, from https://www.masterorganicchemistry.com/2017/07/11/electrophilic-aromatic-substitution-introduction/