Studies on the Effect of Molecular Weight on the Degradation Rate of Biodegradable Polymer Membrane (1)

목차

1 Introduction

2 Materials and methods
2.1 Materials
2.2 Preparation of membrane
2.3 In vitro degradation of membranes

3 Results

4 Conclusions

본문내용

1 Introduction

Biodegradable polymers have been the most attractive device for tissue engineering applications over the past decades. Biodegradable polymers are natural or synthetic and are degraded in vivo, to produce biocompatible, toxicologically safe by-products by the normal metabolic pathways. The biomedical applications of enzymatically degradable nature polymers such as collagen dates back thousands of years, but the biomedical applications of synthetic polymers starter only for decades. Poly lactic acid (PLA) and Poly lactic-co-glycolic acid (PLGA) have shown immense potential as drug delivery carriers and scaffolds. Because they are physically strong and highly biocompatible and have long clinical experience, favorable degradation characteristics. [1-3] The degradation mechanisms and molecular weight change over time of PLGA copolymers have been reported. [4-7] And faster degradation of PLA and PLGA at elevated temperature has been reported. [8-10]

참고자료

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