천연물질의 구강암에 대한 예방 치료 효과

목차

1. 서 론

2. 본 론
2.1 천연물질의 OSCC chemo-prevention mechanism
2.2. 구강암과 천연물질
2.2.1 모나스커스 색소
2.2.2 녹차
2.2.3 curcumin
2.3. 현재 드러난 한계점 및 추후 방향 설정

3. 결 론

4. 참고문헌

본문내용

우리가 쉽게 접하는 과일, 야채, 약초 추출물, 즉 천연물질 에는 이들에 함유된 약효성분의 암 예방 및 항암 효능이 대두되고 있다. 예를 들어 인도의 경우 씹는담배를 많이 사용하기 때문에 구강암의 발생률이 다른 나라에 비해서 매우 높지만 암 예방물질이 포함된 것으로 알려진 카레를 많이 먹기 때문에 전체적인 암 발생률은 다른 국가에 비해서 상대적으로 낮다.
이러한 GRAS(generally recognized as safe)들은 역학적 조사를 통해 생체적합성이 이미 보장되어 있다는 점과 널리 쓰이고 있기에 환자의 입장에서 거부감이 덜하여 임상에 적용하기 쉬운 이점들을 함께 지니고 있다. 따라서 천연물질에 포함되어 있는 암 예방성분을 찾아서 개발하게 된다면 구강암의 발생률 및 발병된 환자들의 사망률을 크게 낮출 수 있으리라 기대하고 있다.

<중 략>

Oral squamous cell carcinoma (OSCC)는 암 중에 가장 빠른 증가폭과 높은 mortality rate을 보이며 여자보다 남자에서 더욱 빈발한다. (Parkin et al., 2001). OSCC는 다양한 원인에 의해 일어나는데 이에는 유전적 취약성, 생활습관 (담배,알콜섭취, 구강 위생 불량, 카로테노이드와 같은 phytochemical 식이의 부족)이 risk factor로 작용한다.
섭취물의 Chemoprevention은 OSCC의 발생을 조절하는 효과적인 전략으로 발전해 왔고 최근의 경향도 이것에 관련된 metabolism을 밝혀내고 암의 치료와 예방에 적용하는 방향으로 나아가고 있다. 본문에서 언급될 실험들을 포함하여 실험상의 animal tumor model에서 사람의 OSCC를 모방하여 실험이 이루어지고 있고, 양성에서 침투성 악성종양으로의 진행을 예방하거나 막기 위해서 역학적이거나 실험적인 연구를 통해 phytochemical과 같은 항암후보물질을 발굴하고자 노력하고 있다.

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