남성 우울증 환자에서 흡연 유무에 따른 Loudness Dependence of the Auditory Evoked Potential의 차이 (Smoking Behavior and Loudness Dependence of the Auditory Evoked Potential among Male Patients with Major Depressive Disorder)

서지정보

· 발행기관 : 대한정신약물학회
· 수록지 정보 : 대한정신약물학회지 / 22권 / 2호 / 89 ~ 95페이지
· 저자명 : 양은경, 김진환, 이승환

초록

본 연구의 한계에도 불구하고 우리의 연구 결과는 우울증환자의 흡연 유무에 따른 LDAEP의 차이에 대한 자료를 제공하며 이는 앞으로 특히 흡연과 관련한 LDAEP에 대한 연구에도움이 될 것으로 여겨진다. 앞으로 흡연과 LDAEP와의 관련성에 대한 연구에서 흡연자 내에서도 흡연 절제 시와 흡연직후의 LDAEP의 차이를 알아보는 연구가 이루어져야 하겠으며, 우울증 환자 이외 정상인 및 기타 정신질환자에서도흡연과 LDAEP의 관련성에 대한 연구가 이루어져야 하겠다.

영어초록

Objective The loudness dependence of the auditory evoked potential (LDAEP) has been known as an indicator of central serotonergic neurotransmission. Nicotine increases the release of serotonin levels. The current study investigated whether cigarette smoking would make difference in LDAEP among male patients with major depressive disorder.
Methods Twenty-four non-smoking and 20 smoking male patients meeting DSM-IV criteria for major depressive disorder (MDD) were recruited. There was no significant difference in severity of MDD symptoms between the two groups. The age of participants ranged from 20 to 65 years old. Event-related potentials (ERP) N100 were measured on 5 different sounds (55, 65, 75,85, 95 dB) and on 5 electrodes (Fz, Cz, Pz, C5, C6). The N1/P2 peak to peak amplitudes and amplitude slope according to 5 different sounds were calculated.
Results LDAEP was significantly weaker in the smoking group in comparison to the non-smoking group (p<0.05). Among non-smoking group LDAEP was negatively correlated with a core depression subscale of Hamilton Rating Scale for Depression (HAM-D) (r=-0.41, p<0.05).
Conclusion LDAEP of the smoking patients with MDD group was weaker than the non-smoking patient with MDD group’s.
This result suggests that smoking may have increased the release of serotonergic neurotransmission in patients with MDD. Future studies need to examine LDAEP changes before and after tobacco use among smoking patients.

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