안면부에 발생한 피부섬유종 13예에 대한 임상조직학적 고찰 (A Clinical and Histopathological Study of 13 Cases of Facial Dermatofibroma)

서지정보

· 발행기관 : 대한피부과학회
· 수록지 정보 : 대한피부과학회지 / 50권 / 8호 / 693 ~ 702페이지
· 저자명 : 최석주, 김정은, 원종현, 장성은, 이미우, 최지호, 문기찬

초록

Background: Dermatofibroma (DF) is one of the most common benign soft tissue tumors, and its diagnosis is not difficult if clinicopathologic features are typical. However, DF occurring on the face is very rare; therefore, it is usually missed clinically.
Objective: This study was conducted to obtain better understanding of the clinicopathologic features of dermatofibroma of the face.
Methods: This is a retrospective study of fibrous histiocytoma of the face at our center over a 23-year period (1989∼2011). Clinicopathologic features of 13 patients were evaluated.
Results: Of the 13 patients, ten were female and three were male. The neoplasms presented with various and atypical features, such as nodule, ulceration and papules. Low-power examination revealed that most of the cases were extended beyond the subcutaneous fat layer, showing ill-defined diffuse infiltrative pattern. The most common histologic type was typical fibrocollagenous type, but some cases presented features of cellular or angiomatous type.
Mitotic activity was not definite in majority of cases, and usually ranged 0∼1 mitoses per 10 HPF and a few atypical cells were shown in 2 cases, but not accompanied by recurrence. Tumor cells in all cases tested were negative for desmin and CD34, but positive for Factor XIIIa and CD68 in majority of the cases.
Conclusion: Because of its rare development on face and diverse clinical presentation, correct diagnosis with differential diagnosis is thought to be important. DF of the face usually presents with infiltration of deeper structures and still shows a benign behavior.

영어초록

Background: Dermatofibroma (DF) is one of the most common benign soft tissue tumors, and its diagnosis is not difficult if clinicopathologic features are typical. However, DF occurring on the face is very rare; therefore, it is usually missed clinically.
Objective: This study was conducted to obtain better understanding of the clinicopathologic features of dermatofibroma of the face.
Methods: This is a retrospective study of fibrous histiocytoma of the face at our center over a 23-year period (1989∼2011). Clinicopathologic features of 13 patients were evaluated.
Results: Of the 13 patients, ten were female and three were male. The neoplasms presented with various and atypical features, such as nodule, ulceration and papules. Low-power examination revealed that most of the cases were extended beyond the subcutaneous fat layer, showing ill-defined diffuse infiltrative pattern. The most common histologic type was typical fibrocollagenous type, but some cases presented features of cellular or angiomatous type.
Mitotic activity was not definite in majority of cases, and usually ranged 0∼1 mitoses per 10 HPF and a few atypical cells were shown in 2 cases, but not accompanied by recurrence. Tumor cells in all cases tested were negative for desmin and CD34, but positive for Factor XIIIa and CD68 in majority of the cases.
Conclusion: Because of its rare development on face and diverse clinical presentation, correct diagnosis with differential diagnosis is thought to be important. DF of the face usually presents with infiltration of deeper structures and still shows a benign behavior.

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