염증성 장질환에 동반된 악성종양 (Malignancy Associated with Inflammatory Bowel Disease)

서지정보

· 발행기관 : 대한대장항문학회
· 수록지 정보 : Annals of Coloproctolgy / 25권 / 3호 / 150 ~ 156페이지
· 저자명 : 신의섭, 유창식, 김찬욱, 박진석, 정광용, 윤상남, 임석병, 송준선, 김진천

초록

Purpose: As the number of patients with inflammatory bowel disease (IBD) has steadily increased in Korea, IBD-associated
cancers are expected to increase in number. This study investigated the clinical features of intestinal cancer in patients with
IBD.
Methods: One hundred five patients with ulcerative colitis (UC) and 270 patients with Crohn’s disease (CD) under the care
of the Department of Colon and Rectal Surgery, Asan Medical Center, between December 1989 and January 2009 were
reviewed retrospectively.
Results: Ten patients of the 105 with UC and 5 patients of the 270 with CD were found to have intestinal cancer. The mean
age was 45 yr (±8.8), and the mean duration of IBD at the time of diagnosis of the cancer was 12.6 yr (±6.0). Six of the
15 cancer patients had no history of treatment for IBD of more than 3 mo before diagnosis of the cancer. Eleven cancers were
located in the rectum (7 in UC, 4 in CD), including 1 case of synchronous cancer. One case of small bowel cancer was found
in a patient with small bowel CD. Four cases involved a mucinous adenocarcinoma. Eight of the 12 cases of an adenocarcinoma
of the colon and rectum were advanced stage.
Conclusion: IBD-associated intestinal cancers were found at a relatively young age, were diagnosed at an advanced stage,
and had a higher proportion of mucinous adenocarcinomas than in sporadic cancer. Considering the increasing incidence
of IBD and the expected increase in the number of IBD-associated cancer in Korea, every effort should be made to prevent
intestinal cancer in patients with IBD and to detect it early.

영어초록

Purpose: As the number of patients with inflammatory bowel disease (IBD) has steadily increased in Korea, IBD-associated
cancers are expected to increase in number. This study investigated the clinical features of intestinal cancer in patients with
IBD.
Methods: One hundred five patients with ulcerative colitis (UC) and 270 patients with Crohn’s disease (CD) under the care
of the Department of Colon and Rectal Surgery, Asan Medical Center, between December 1989 and January 2009 were
reviewed retrospectively.
Results: Ten patients of the 105 with UC and 5 patients of the 270 with CD were found to have intestinal cancer. The mean
age was 45 yr (±8.8), and the mean duration of IBD at the time of diagnosis of the cancer was 12.6 yr (±6.0). Six of the
15 cancer patients had no history of treatment for IBD of more than 3 mo before diagnosis of the cancer. Eleven cancers were
located in the rectum (7 in UC, 4 in CD), including 1 case of synchronous cancer. One case of small bowel cancer was found
in a patient with small bowel CD. Four cases involved a mucinous adenocarcinoma. Eight of the 12 cases of an adenocarcinoma
of the colon and rectum were advanced stage.
Conclusion: IBD-associated intestinal cancers were found at a relatively young age, were diagnosed at an advanced stage,
and had a higher proportion of mucinous adenocarcinomas than in sporadic cancer. Considering the increasing incidence
of IBD and the expected increase in the number of IBD-associated cancer in Korea, every effort should be made to prevent
intestinal cancer in patients with IBD and to detect it early.

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