흰쥐 관절염 모델에서 용천 저출력 레이저 자극이 보행행동에 미치는 영향 (Effects of Low Level Laser Treatment Applied to KI 1 on the Gait Behavior in the Rat Model of CFA-Induced Arthritis)

서지정보

· 발행기관 : 경락경혈학회
· 수록지 정보 : Korean Journal of Acupuncture / 32권 / 1호 / 30 ~ 38페이지
· 저자명 : 지병욱, 이성금, 이지은, 구성태

초록

Objectives : The aim of the study is to investigate the effects of low level laser treatment (LLLT) on the gait behavior in the rat modelof arthritis. Methods : Knee arthritis was induced by the injection of 125 μl of Complete Freund`s Adjuvant(CFA) into the right hindknee joint cavity. Arthritic rats were divided 3 groups; arthritis group was used for control(CON), 10 min of laser treated group(LSR10), and 30 min of laser treated group(LSR30). LLLT was applied to KI 1 for 11 times under gaseous anesthesia. We performedseveral analyses under catwalk test including stand and swing time, duty cycle of paw steps, intensity and print area of steps, andstride length. Results : Stand and duty cycle of paw steps were increased significantly at 12 days after arthritis induction in LSR30group. Swing time was decreased significantly at 12 days after arthritis induction in LSR10 group. In the analysis of intensity, printarea and stride length, however, results did not show statistical significance during the time point of experiments. Conclusions :The data suggest that LLLT on the rat model of CFA induced arthritis showed beneficial effects by increase of stand time and dutycycle of paw steps and decrease of swing time. Therefore, LLLT could be useful option to improve gait discomfort in arthritispatients.

영어초록

Objectives : The aim of the study is to investigate the effects of low level laser treatment (LLLT) on the gait behavior in the rat modelof arthritis. Methods : Knee arthritis was induced by the injection of 125 μl of Complete Freund`s Adjuvant(CFA) into the right hindknee joint cavity. Arthritic rats were divided 3 groups; arthritis group was used for control(CON), 10 min of laser treated group(LSR10), and 30 min of laser treated group(LSR30). LLLT was applied to KI 1 for 11 times under gaseous anesthesia. We performedseveral analyses under catwalk test including stand and swing time, duty cycle of paw steps, intensity and print area of steps, andstride length. Results : Stand and duty cycle of paw steps were increased significantly at 12 days after arthritis induction in LSR30group. Swing time was decreased significantly at 12 days after arthritis induction in LSR10 group. In the analysis of intensity, printarea and stride length, however, results did not show statistical significance during the time point of experiments. Conclusions :The data suggest that LLLT on the rat model of CFA induced arthritis showed beneficial effects by increase of stand time and dutycycle of paw steps and decrease of swing time. Therefore, LLLT could be useful option to improve gait discomfort in arthritispatients.

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