국내 기무라병의 임상적 특성 (Clinical Characteristics of Kimura Disease in Korea)

서지정보

· 발행기관 : 대한천식알레르기학회
· 수록지 정보 : 천식 및 알레르기 / 30권 / 4호 / 285 ~ 292페이지
· 저자명 : 강민구, 김병근, 강성윤, 김미영, 이서영, 김태완, 이소희, 김세훈, 강혜련, 장윤석, 김선신, 조상헌, 민경업, 박흥우

초록

Background: The Kimura disease, a chronic inflammatory disorder of unknown etiology, is characterized by subcutaneous mass, regional lymphadenopathy, peripheral blood eosinophilia or increased serum immunoglobulin E level. So far, there has been limited information concerning this disease.
Objective: To investigate clinical features of Kimura disease in Korea.
Method: We retrospectively reviewed 33 patients who had a histologically proven Kimura disease from January 1995to March 2010 at Hospital. Then clinical features and treatment outcomes were evaluated.
Result: Of all patients, 28 were male (84.8%), and mean age was 25.2±15.1 years. Involved sites were as follows;preauricular (n=8), upper arm (n=8), retroauricular (n=6),submandibular (n=4), eyelid (n=4), inguinal (n=4), and cervical area (n=4). Peripheral blood eosinophilia was observed in 87.1% of patients. Twenty-seven patients were treated by operation, corticosteroids, or radiation, and the other 6 were just followed without any intervention. Among the 27 patients treated, only 12 have achieved a state of control. Treatment outcomes in terms of size and mass numbers were variable.
Conclusion: Kimura disease should be ruled out in young male who shows painless soft tissue swellings with peripheral blood eosinophilia in Korea. The optimal management for Kimura disease needs to be investigated further.

영어초록

Background: The Kimura disease, a chronic inflammatory disorder of unknown etiology, is characterized by subcutaneous mass, regional lymphadenopathy, peripheral blood eosinophilia or increased serum immunoglobulin E level. So far, there has been limited information concerning this disease.
Objective: To investigate clinical features of Kimura disease in Korea.
Method: We retrospectively reviewed 33 patients who had a histologically proven Kimura disease from January 1995to March 2010 at Hospital. Then clinical features and treatment outcomes were evaluated.
Result: Of all patients, 28 were male (84.8%), and mean age was 25.2±15.1 years. Involved sites were as follows;preauricular (n=8), upper arm (n=8), retroauricular (n=6),submandibular (n=4), eyelid (n=4), inguinal (n=4), and cervical area (n=4). Peripheral blood eosinophilia was observed in 87.1% of patients. Twenty-seven patients were treated by operation, corticosteroids, or radiation, and the other 6 were just followed without any intervention. Among the 27 patients treated, only 12 have achieved a state of control. Treatment outcomes in terms of size and mass numbers were variable.
Conclusion: Kimura disease should be ruled out in young male who shows painless soft tissue swellings with peripheral blood eosinophilia in Korea. The optimal management for Kimura disease needs to be investigated further.

참고자료

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