수도권 학령전기 소아에서 식품알레르기의 유병률 및 위험인자 (Prevalence and Risk Factors of Food Allergy in Preschool Children in Seoul)

서지정보

· 발행기관 : 대한천식알레르기학회
· 수록지 정보 : 천식 및 알레르기 / 31권 / 3호 / 177 ~ 183페이지
· 저자명 : 정영호, 고훈, 김영형, 서주희, 권지원, 김병주, 김효빈, 이소연, 장광천, 송대진, 김우경, 심정연, 홍수종

초록

Background: The aim of this study was to investigate the prevalence of food allergy (FA) and determine its risk factors in the preschool urban children in Seoul, Korea.
Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. The risk factor analysis was done by logistic regression analysis.
Results: In preschool children, the lifetime and recent 12-month prevalence of FA symptoms were 21.0% and 10.6%,respectively. The lifetime prevalence of FA diagnosis was 6.1%, the prevalence of current FA (12-month symptoms and diagnosis) was 3.3%, and the recent 12-month prevalence of FA treatment was 3.6%. Blood eosinophils [0] in FA group and Non-FA group were 5.00±3.93% and 3.93±2.91%,respectively (P=0.002). The median total Immunoglobulin E (IgE) of FA group was 102 (interquatile [IQ] range 44.8∼257) IU/mL, the median total IgE of Non-FA group was 70.9 (IQ range 70.9∼161) IU/mL (P=0.001). Parental FA (adjusted odds ratio [aOR], 2.17; 95% confidence interval [CI], 1.22∼3.85), past history of AD diagnosis (aOR, 3.69;95% CI, 2.33∼5.85), eczema on doctor’s physical examination (aOR, 3.74; 95% CI, 2.16∼6.47), use of antibiotics during infancy more than 3 days (aOR, 1.72; 95% CI, 1.08∼2.73) were the independent risk factors for FA symptoms within 12 months.
Conclusion: In preschool urban children in Seoul, the lifetime prevalence of FA diagnosis was 6.1%, the recent 12month prevalence of FA treatment was 3.6%. The prevalences of AD and doctor examined AD in FA group were significantly higher compared to Non-FA group. Family history,and the use of antibiotics during infancy could be the independent risk factors for the development of FA.

영어초록

Background: The aim of this study was to investigate the prevalence of food allergy (FA) and determine its risk factors in the preschool urban children in Seoul, Korea.
Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. The risk factor analysis was done by logistic regression analysis.
Results: In preschool children, the lifetime and recent 12-month prevalence of FA symptoms were 21.0% and 10.6%,respectively. The lifetime prevalence of FA diagnosis was 6.1%, the prevalence of current FA (12-month symptoms and diagnosis) was 3.3%, and the recent 12-month prevalence of FA treatment was 3.6%. Blood eosinophils [0] in FA group and Non-FA group were 5.00±3.93% and 3.93±2.91%,respectively (P=0.002). The median total Immunoglobulin E (IgE) of FA group was 102 (interquatile [IQ] range 44.8∼257) IU/mL, the median total IgE of Non-FA group was 70.9 (IQ range 70.9∼161) IU/mL (P=0.001). Parental FA (adjusted odds ratio [aOR], 2.17; 95% confidence interval [CI], 1.22∼3.85), past history of AD diagnosis (aOR, 3.69;95% CI, 2.33∼5.85), eczema on doctor’s physical examination (aOR, 3.74; 95% CI, 2.16∼6.47), use of antibiotics during infancy more than 3 days (aOR, 1.72; 95% CI, 1.08∼2.73) were the independent risk factors for FA symptoms within 12 months.
Conclusion: In preschool urban children in Seoul, the lifetime prevalence of FA diagnosis was 6.1%, the recent 12month prevalence of FA treatment was 3.6%. The prevalences of AD and doctor examined AD in FA group were significantly higher compared to Non-FA group. Family history,and the use of antibiotics during infancy could be the independent risk factors for the development of FA.

참고자료

· 없음