한국인 유방암의 역학적 특성 (Epidemiologic Characteristics of the Breast Cancer in Korea)

서지정보

· 발행기관 : 대한의사협회
· 수록지 정보 : 대한의사협회지 / 52권 / 10호 / 937 ~ 945페이지
· 저자명 : 박수경, 강대희, 김연주, 유근영

초록

Breast cancer has been the most common cancer among Korean women since 2001 and will
continue to increase for the next 20 years, at the least. Many of the established risk factors
are linked to the exposure to female hormones: breast cancer risk is increased by early
menarche, late menopause, nulliparity and later first full-term pregnancy, and obesity in
postmenopausal women. In addition, other established risk factors such as alcohol consumption
and family history of breast cancer are associated with an increased risk of breast cancer.
Physical activity, breast feeding, higher number of children, and fruit and vegetable consumption
seem to reduce breast cancer risk. Smoking also probably increases the risk. Both oral
contraceptives in premenopausal women and hormonal replacement therapy in postmenopausal
women may increase risk. Above-mentioned risk and protective factors were reported in Korean
populations and the breast cancer risk by those factors is similar to that in western population.
Currently, a study is being done in Korea to examine the associated risk, and population
attributable risk of genetic variants in high penetrance genes including BRCA 1 and 2 and breast
cancer risk among Koreans will be reported soon. Other studies conducted in Korea that
investigated low penetrance genes have already been published. While the individual risk was
small, there was an effect from interaction with environmental factors. Numerous Korean studies
about these risk factors helped to establish a model to predict individual breast cancer risk that is
utilized in the Personalized Preventive and Predictive medicine.

영어초록

Breast cancer has been the most common cancer among Korean women since 2001 and will
continue to increase for the next 20 years, at the least. Many of the established risk factors
are linked to the exposure to female hormones: breast cancer risk is increased by early
menarche, late menopause, nulliparity and later first full-term pregnancy, and obesity in
postmenopausal women. In addition, other established risk factors such as alcohol consumption
and family history of breast cancer are associated with an increased risk of breast cancer.
Physical activity, breast feeding, higher number of children, and fruit and vegetable consumption
seem to reduce breast cancer risk. Smoking also probably increases the risk. Both oral
contraceptives in premenopausal women and hormonal replacement therapy in postmenopausal
women may increase risk. Above-mentioned risk and protective factors were reported in Korean
populations and the breast cancer risk by those factors is similar to that in western population.
Currently, a study is being done in Korea to examine the associated risk, and population
attributable risk of genetic variants in high penetrance genes including BRCA 1 and 2 and breast
cancer risk among Koreans will be reported soon. Other studies conducted in Korea that
investigated low penetrance genes have already been published. While the individual risk was
small, there was an effect from interaction with environmental factors. Numerous Korean studies
about these risk factors helped to establish a model to predict individual breast cancer risk that is
utilized in the Personalized Preventive and Predictive medicine.

참고자료

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