폐에 존재하는 Clara Cell의 역할

소개

저널클럽에서 발표했던 자료입니다.
폐에 정상적으로 존재하며 injury repair와 carcinogenesis (암 발생)에 관여하는 clara cell에 대한 review입니다.
조직학 또는 해부학, 생화학 대학원 등에서 활용하시면 좋을 것 같습니다.

목차

1. Introduction
2. Clara cell diversity
3. Origin and plasticity : Establishment of the Clara cell pool
4. Functions : As reparative cells for the airway epithelium
5. Associated pathologies : Clara cells and cancer
6. Cell Facts Summary

본문내용

The Clara cell
Cubiodal, nonciliated cell in terminal bronchioles
Basally-situated nucleus
Apical dome extending variable distances into the airway lumen
Discrete, oval densely-staining granules
Multifunctional cell
Barrier maintenance, Secretion, and Metabolism (Stripp and Reynolds, 2006)
Antibody reagents specific to the secretoglobin (SCGB1A1) family identifies Clara cell on the basis of secreted protein expression (Reynolds et al., 2002).
Uteroglobin (Ug) in humans and rabbits

<중 략>

A. Triple color image in which CCSP (red), proSPC (green), and nuclei (blue) are detected by dual immunofluorescence. CCSP-proSPC dual positive cells are indicated by yellow arrows. Airway CCSP+ cells are intentionally overstained to allow detection of CCSP+ tumor cells.
B. Analysis of label-retaining cells. Cells “born” 120 days prior to analysis are indicated by autoradiographic grains (black dots). Cells of similar age in unaffected airway (blue arrow) and in tumor tissue (black arrows) are shown at higher magnification in insets C and D.

참고자료

· Clara Cell: Progenitor for the Bronchiolar Epithelium
· Int J Biochem Cell Biol. 2010 January; 42(1): 1 4.