후성유전체 연구동향 분석 및 한의약 활용 방안 연구 (Analysis of the epigenome research trends and study on utilization of Korean Medicine)

서지정보

· 발행기관 : 한약정보연구회
· 수록지 정보 : 한약정보연구회지(韓藥情報硏究會誌) / 6권 / 2호 / 279 ~ 288페이지
· 저자명 : 김철, 성보석, 장윤지

초록

The epigenesis is a phenomenon in which genetic information is expressed differently due to inherited factors such as environment, habit, and virus infection without changing the gene base sequence itself. Although many researchers could reveal many secrets of life through deciphering the human genome sequence, many studies using epigenetic have been attempted because genome had difficulty in explaining the various disease incidence. Large-scale projects are being actively carried out globally, and Korea is also participating in this project. We investigated what kind of research was carried out internationally using the epigenome and analyzed the technical factors that are needed to start the study of the epigenetic genome in this paper. We investigated applicable research areas using these techniques and introduced one epigenome project that our team has actually done. Our study used integrated network between DNA methylation and expression, identify epigenetic regulating network hub genes associated with anti-asthmatic effects by D. sophia seed extract (DSE) treatment in OVA-induced mouse model. We hope that the results of this study will lead to the development of diverse epigenetic studies in the field of Korean medicine.

영어초록

The epigenesis is a phenomenon in which genetic information is expressed differently due to inherited factors such as environment, habit, and virus infection without changing the gene base sequence itself. Although many researchers could reveal many secrets of life through deciphering the human genome sequence, many studies using epigenetic have been attempted because genome had difficulty in explaining the various disease incidence. Large-scale projects are being actively carried out globally, and Korea is also participating in this project. We investigated what kind of research was carried out internationally using the epigenome and analyzed the technical factors that are needed to start the study of the epigenetic genome in this paper. We investigated applicable research areas using these techniques and introduced one epigenome project that our team has actually done. Our study used integrated network between DNA methylation and expression, identify epigenetic regulating network hub genes associated with anti-asthmatic effects by D. sophia seed extract (DSE) treatment in OVA-induced mouse model. We hope that the results of this study will lead to the development of diverse epigenetic studies in the field of Korean medicine.

참고자료

· 없음