극소 저체중 신생아의 예제제 정맥영양수액 공급에 의한 임상적 효과 평가 (Clinical Efficacy of Starter Parenteral Nutrition in Very Low Birth Weight Infants)

서지정보

· 발행기관 : 한국병원약사회
· 수록지 정보 : 병원약사회지 / 38권 / 4호 / 462 ~ 472페이지
· 저자명 : 성지현, 임나리, 전은용, 이후경, 성세인, 민명숙

초록

Background : Preterm infants including very low birth weight infants (VLBWIs) and extremely low birth weight infants (ELBWIs) have high rates of protein turnover and low nutrient reserves. Therefore, parenteral nutrition (PN) should be initiated within 24 hours after birth if it is anticipated that they will be unable to tolerate enteral feeding for more than 2 to 3 days. However, in our institution, in cases of babies born on holidays and weekends, it is difficult to supply individualized PN including amino acids. So we supply starter PN (SPN) every Saturday and holiday, for use in case of emergency. We intended to evaluate the clinical efficacy of SPN on short-term growth and nutritional supply, especially for preterm infants.
Methods : We retrospectively reviewed the medical records of preterm infants with a birth weight of less than 1,500 g who were born and admitted to the neonatal intensive care unit (NICU) of the Samsung Medical Center between March 2015 and May 2020. The patients were categorized into two groups according to whether they received SPN or not. We compared perinatal characteristics, nutrition supply, anthropometric measurements, and laboratory findings between the two groups.
Results : Of the 82 patients, 40 infants were in the SPN group. Gestational age (p<0.001) and one minute Apgar score (p<0.001), and calories supplied over the first two weeks were lower in the SPN group (p=0.014). However, the rate of weight gain was higher in the SPN group (p=0.007). Most laboratory test results were significantly different between the two groups.
Conclusion : SPN can improve the short-term growth of preterm infants. Lower gestational age seems to be the cause of relatively high values of laboratory test results including BUN and blood glucose as well as low caloric intake in the SPN group.

영어초록

Background : Preterm infants including very low birth weight infants (VLBWIs) and extremely low birth weight infants (ELBWIs) have high rates of protein turnover and low nutrient reserves. Therefore, parenteral nutrition (PN) should be initiated within 24 hours after birth if it is anticipated that they will be unable to tolerate enteral feeding for more than 2 to 3 days. However, in our institution, in cases of babies born on holidays and weekends, it is difficult to supply individualized PN including amino acids. So we supply starter PN (SPN) every Saturday and holiday, for use in case of emergency. We intended to evaluate the clinical efficacy of SPN on short-term growth and nutritional supply, especially for preterm infants.
Methods : We retrospectively reviewed the medical records of preterm infants with a birth weight of less than 1,500 g who were born and admitted to the neonatal intensive care unit (NICU) of the Samsung Medical Center between March 2015 and May 2020. The patients were categorized into two groups according to whether they received SPN or not. We compared perinatal characteristics, nutrition supply, anthropometric measurements, and laboratory findings between the two groups.
Results : Of the 82 patients, 40 infants were in the SPN group. Gestational age (p<0.001) and one minute Apgar score (p<0.001), and calories supplied over the first two weeks were lower in the SPN group (p=0.014). However, the rate of weight gain was higher in the SPN group (p=0.007). Most laboratory test results were significantly different between the two groups.
Conclusion : SPN can improve the short-term growth of preterm infants. Lower gestational age seems to be the cause of relatively high values of laboratory test results including BUN and blood glucose as well as low caloric intake in the SPN group.

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