수인성 니코틴 노출에 의한 금붕어(Carassius auratus)의 폐사율, 혈액학적 성상 및 조직병리학적 변화에서의 영향 (Effects on the mortality rate, hematological parameters and histopathological changes in goldfish, Carassius auratus exposed to waterborne nicotine)

서지정보

· 발행기관 : 한국어병학회
· 수록지 정보 : 한국어병학회지 / 37권 / 2호 / 331 ~ 341페이지
· 저자명 : 이희종, 나정현, 박지원, 권세련, 송준영

초록

In this study, the toxicity of goldfish exposed to nicotine at concentrations of 0, 2.5, 5.0, 7.5, and 10.0 ppm for 120 h was evaluated. The 50% lethal dose (LD50) of nicotine for goldfish was determined to be 5.0 ppm, and concentrations above 7.5 ppm resulted in 100% mortality within 24 hours of exposure. Hematobiochemical analysis of goldfish exposed to nicotine showed significant increases in GLU, ALT, AST, and BUN, and decreases in ALP compared to the control group, suggest- ing that nicotine exposure caused damage to the liver and kidneys of the fish. In addition, histopatho- logical analysis results showed hyperplasia of the gill primary lamellae epithelium, cloudy swelling of the renal tubular epithelium, hepatic congestion, and hyaline degeneration in liver cells, which were consistent with the results of liver and kidney damage by hematobiochemical analysis. This study provides insight into the potential impacts of nicotine exposure on fish ecosystems and highlights the need for continued research on nicotine contamination in natural aquatic systems

영어초록

In this study, the toxicity of goldfish exposed to nicotine at concentrations of 0, 2.5, 5.0, 7.5, and 10.0 ppm for 120 h was evaluated. The 50% lethal dose (LD50) of nicotine for goldfish was determined to be 5.0 ppm, and concentrations above 7.5 ppm resulted in 100% mortality within 24 hours of exposure. Hematobiochemical analysis of goldfish exposed to nicotine showed significant increases in GLU, ALT, AST, and BUN, and decreases in ALP compared to the control group, suggest- ing that nicotine exposure caused damage to the liver and kidneys of the fish. In addition, histopatho- logical analysis results showed hyperplasia of the gill primary lamellae epithelium, cloudy swelling of the renal tubular epithelium, hepatic congestion, and hyaline degeneration in liver cells, which were consistent with the results of liver and kidney damage by hematobiochemical analysis. This study provides insight into the potential impacts of nicotine exposure on fish ecosystems and highlights the need for continued research on nicotine contamination in natural aquatic systems

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