암세포 특이적 세포 사멸을 유도하는 자생식물 추출물의 항암 효과

서지정보

· 발행기관 : 한국생약학회
· 수록지 정보 : 생약학회지 / 40권 / 1호 / 6 ~ 12페이지
· 저자명 : 윤이관, 이승은, 이동진, 노문철, 성정숙, 박충범, 장영주

초록

Thirty five methanol extracts from 19 natural local plants, which have been used as traditional anti-cancer medicine,
were prepared. They were analyzed the cytotoxic effects on primary fibroblast cells and carcinoma cells. The root extract of
Solanum nigrum were highly toxic in both cell lines with IC50 values of less than 0.01 µg/µl, and 26 of 35 extracts were toxic
in all cells with IC50 values of 0.1~2 µg/µl. Three extracts including the fruit extracts of Solanum nigrum and Morus alba had
no cytotoxic activity in both cell lines. Five of 35 extracts were highly toxic in cancer cells than in primary cells. Because primary
cells were more resistant on these extracts, the five extracts were selected for anti-cancer agent candidates. Apoptosis o r
programmed cell death has an essential role in chemotherapy-induced tumor cell killing. Recently, inducers of apoptosis have
been used in cancer therapy. When two of 5 cancer cell-specific cytotoxic extracts (Ulmus parvifolia and Zelkova serrata) were
treated in concentration of 0.02~0.1 µg/µl, apoptosis were increased at 3-5 times in cancer cell lines. Finally, the apoptotic
effects of these extracts were confirmed by cleavages of both poly-(ADP-ribose)-polymerase and caspase-3 as apoptotic markers.
In this report, we suggested that two of 35 medicinal herb extracts can be useful anti-cancer drug candidates inducing apo -
ptosis in several carcinoma cell lines.

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