Human coronavirus infection in hospitalized children with community-acquired pneumonia

서지정보

· 발행기관 : 대한소아감염학회
· 수록지 정보 : Pediatric Infection and Vaccine / 14권 / 1호 / 69 ~ 74페이지
· 저자명 : 정주영, 한태희, 김상우, 구자욱, 황응수

초록

Purpose : Human coronanviruses (hCovs) including hCoV-229E and hCoV-OC43 have been
known as etiologic agents of the common colds and were regarded as clinically insignificant
agents. However, recent identification of hCoV-NL63 and hCoV-HKU1 in children with
lower respiratory tract infections has evoked the clinical concerns about their prevalence
and the clinical significance of these hCoVs in children. This study was performed to investigate
the prevalence of hCoVs in children with community-acquired pneumonia.
Methods : From March 2006 to January 2007, nasopharyngeal specimens collected from
children hospitalized with pneumonia, were tested for the presence of common respiratory
viruses (respiratory syncytial virus, influenza A, influenza B, parainfluenza viruses, and adenovirus)
using multiplex reverse transcriptase polymerase chain reaction (RT-PCR). Human
metapneumovirus (hMPV) infection was excluded by nested RT-PCR using primers for the
F-gene. To detect the different strains of hCoVs, nested RT-PCR assays specific for hCoVNL63,
hCoV-OC43, hCoV-229E, and hCoV-HKU1 were performed.
Results : Out of the 217 nasopharyngeal aspirate from children aged under 15 years, respiratory
syncytial virus (RSV) was detected in 32 patients, hMPV in 18, human parainfluenza
virus in 10, influenza virus A in 2, and adenovirus in 6. HCoVs were detected by
RT-PCR in 8 (3.7%) of the 217 patients, hCoV-229E in 1, hCoV-NL63 in 3, and hCoVOC43
in 4 patients. HCoV-HKU1 was not detected in this study population.
Conclus ion : Recently identified hCoV-NL63 and hCoV-HKU1 seemed to have a little
clinical significance in Korean children with severe or hospitalized community-acquired
pneumonia. (Korean J Pediatr Infect Dis 2007;14:69-74)

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