알츠하이머병 환자에서 정신증적 증상과 연관된 좌측 판개부 및 좌측 외측 후두회의 피질 두께 변화 (Altered Cortical Thicknesses of Left Pars Opercularis and Left Lateral Occipital Gyrus Can Be Associated with Psychotic Symptoms in Patients with Alzheimer’s Disease)

서지정보

· 발행기관 : 대한노인정신의학회
· 수록지 정보 : 노인정신의학 / 21권 / 2호 / 67 ~ 74페이지
· 저자명 : 이두형, 김경미, 박선철, 김태형, 최승은, 정태영, 이봉주, 문치웅, 이정구, 김영훈

초록

Objective：The aims of this study was to present an association between the presence of psychotic symptoms and cortical thicknesses/ subcortical volumes in patients with Alzheimer’s disease (AD).
Methods：Fourteen AD patients with psychotic symptoms and 41 without psychotic symptoms underwent 3T MRI scanning. After adjusting the effects of confounding variables, the cortical thicknesses were compared between the AD patients with and without psychotic symptoms in multiple regions, across the continuous cortical surface. In addition, the subcortical volumes were compared with a structure-by-structure manner.
Results：AD patients with psychotic symptoms were characterized by significant smaller cortical thickness of left pars opercularis (F=4.67, p=0.02) and left lateral occipital gyrus (F=6.05, p=0.04) rather than those without psychotic symptoms, after adjusting the effects of age and scores on the Stroop test, non-psychotic items of Neuropsychiatry Inventory and Clinical Dementia Rating, triglyceride level and total intracranial volume. However, there were no significant differences in the subcortical volume between the two groups.

영어초록

Objective：The aims of this study was to present an association between the presence of psychotic symptoms and cortical thicknesses/ subcortical volumes in patients with Alzheimer’s disease (AD).
Methods：Fourteen AD patients with psychotic symptoms and 41 without psychotic symptoms underwent 3T MRI scanning. After adjusting the effects of confounding variables, the cortical thicknesses were compared between the AD patients with and without psychotic symptoms in multiple regions, across the continuous cortical surface. In addition, the subcortical volumes were compared with a structure-by-structure manner.
Results：AD patients with psychotic symptoms were characterized by significant smaller cortical thickness of left pars opercularis (F=4.67, p=0.02) and left lateral occipital gyrus (F=6.05, p=0.04) rather than those without psychotic symptoms, after adjusting the effects of age and scores on the Stroop test, non-psychotic items of Neuropsychiatry Inventory and Clinical Dementia Rating, triglyceride level and total intracranial volume. However, there were no significant differences in the subcortical volume between the two groups.

참고자료

· 없음