열처리녹차추출물 및 효소처리루틴 복합물(AdiPhenonTM)의 지질 대사 및 인슐린 의존적 포도당 흡수 개선 효과 (AdiPhenonTM Improves Lipid Metabolism and Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes)

서지정보

· 발행기관 : 한국식품영양과학회
· 수록지 정보 : 한국식품영양과학회지 / 54권 / 1호 / 11 ~ 21페이지
· 저자명 : 정현우, 박제홍, 남현진, 정진오, 서병휘, 손종희

초록

열처리녹차추출물과 효소처리루틴 복합물인 AdiPhenon은 지방세포 내 지방산 합성을 저해하지만 지방산 산화는 촉진하여 지방세포 내 지질 축적을 억제할 수 있다. 또한, 지방을 연소시켜 에너지를 생성하는 세포 소기관인 미토콘드리아를 증가시키며, 각종 대사성 질환 및 노화의 원인이 되는 염증 반응을 억제한다. 염증 반응은 인슐린 저항성을 유발하여 각종 대사성 질환을 일으키는데, AdiPhenon은 지질 대사뿐 아니라 지방세포 내 인슐린 민감도 또한 개선하여 비만 이외에도 내당능장애, 당뇨병 등의 대사성 질환의 개선에도 효과를 보일 것으로 생각된다.

영어초록

There has been a steady increase in the prevalence of obesity in the past few decades. Since obesity is a major causal factor for various metabolic diseases including insulin resistance, type 2 diabetes, hyperlipidemia, hypertension, atherosclerosis, hepatic steatosis and their complications, the prevention or treatment of obesity is essential for maintaining a healthy life. Enhancing lipid catabolism can improve obesity and related metabolic disorders. In this study, we demonstrated the efficacy of AdiPhenonTM, a mixture of heat treated green teat extract and enzymatically modified isoquercitrin in preventing triglyceride accumulation in differentiated 3T3-L1 adipocytes. AdiPhenonTM inhibited the mRNA expression of lipogenesis-related genes, whereas it augmented that of the fatty acid oxidation-related genes. AdiPhenonTM also induced mitochondrial biogenesis, indicating that it can promote energy expenditure in adipocytes. The beneficial effects of AdiPhenonTM on lipid metabolism are mediated by the activation of AMP-activated protein kinase (AMPK), a master regulator of catabolic energy metabolism. Interestingly, AdiPhenonTM suppressed the mRNA expression of inflammation-related genes, which is closely related to insulin resistance, in an AMPK independent manner, and ameliorated the inflammation-related impairment of insulin-stimulated glucose uptake. Considering the role and effect of chronic inflammation in the progression of obesity-mediated metabolic syndromes, we propose AdiPhenonTM as a novel material for treating obesity and related metabolic disorders.

참고자료

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