류마티스 관절염 흰쥐에서 수중운동과 우슬추출물이 염증 및 통증 반응에 미치는 영향 (Effect of Swimming Exercise and Achyranthes Radix Extracts on Inflammatory and Pain Responses in Rheumatoid Arthritis Rats)

서지정보

· 발행기관 : 한의병리학회
· 수록지 정보 : 동의생리병리학회지 / 23권 / 1호 / 113 ~ 120페이지
· 저자명 : 최기복, 남기원, 심기철, 김은정, 김계엽

초록

This study was performed to investigate the effects in inflammatory and pain status on rheumatoid arthritis(RA) induced rats by swimming exercise and Achyranthes Radix(AR) extracts ointment according to the application methods with the change of motor-behavioral and histochemistry study through the change of safranin o-fast green stain in the knee joint and prostaglandin E2(PGE2) concentration production in serum for 28 days. They were randomly divided into four groups; Group Ⅰ: RA induction, Group Ⅱ: application of only swimming exercise after RA induction, Group Ⅲ: application of only AR extracts ointment after RA induction, Group Ⅳ: application of both AR extracts ointment and swimming exercise after RA induction. The following results were obtained. Volume change of hind paw edema and arthritis indices test and arthritic dorsal flexion & plantar flexion pain test, group Ⅱ, Ⅲ, Ⅳ were showed that significantly decrease to each scores compared with group Ⅰ(p<.01). Safranin o-fast green stain were showed histological indices, group Ⅱ, Ⅲ, Ⅳ were showed that significantly decrease the scores of cellular infiltration and synovial hyperplasia(p<.05), pannus formation and cartilage destruction(p<.01) compared with group Ⅰ. Group Ⅳ were the most decreased compared with group Ⅱ, Ⅲ. The PGE2 concentration of the group Ⅱ, Ⅲ, Ⅳ were decreased compared to the group Ⅰ(p<.01) In conclusion, swimming exercise and AR extracts ointment acts were the most therapeutic intervention in inflammatory and pain control of RA induced rats.

영어초록

This study was performed to investigate the effects in inflammatory and pain status on rheumatoid arthritis(RA) induced rats by swimming exercise and Achyranthes Radix(AR) extracts ointment according to the application methods with the change of motor-behavioral and histochemistry study through the change of safranin o-fast green stain in the knee joint and prostaglandin E2(PGE2) concentration production in serum for 28 days. They were randomly divided into four groups; Group Ⅰ: RA induction, Group Ⅱ: application of only swimming exercise after RA induction, Group Ⅲ: application of only AR extracts ointment after RA induction, Group Ⅳ: application of both AR extracts ointment and swimming exercise after RA induction. The following results were obtained. Volume change of hind paw edema and arthritis indices test and arthritic dorsal flexion & plantar flexion pain test, group Ⅱ, Ⅲ, Ⅳ were showed that significantly decrease to each scores compared with group Ⅰ(p<.01). Safranin o-fast green stain were showed histological indices, group Ⅱ, Ⅲ, Ⅳ were showed that significantly decrease the scores of cellular infiltration and synovial hyperplasia(p<.05), pannus formation and cartilage destruction(p<.01) compared with group Ⅰ. Group Ⅳ were the most decreased compared with group Ⅱ, Ⅲ. The PGE2 concentration of the group Ⅱ, Ⅲ, Ⅳ were decreased compared to the group Ⅰ(p<.01) In conclusion, swimming exercise and AR extracts ointment acts were the most therapeutic intervention in inflammatory and pain control of RA induced rats.

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