레스베라트롤 포집을 위한 제인-리피드 복합 나노입자에 관한 연구 (Study on Zein-Lipid Composite Nanoparticles for Resveratrol Encapsulation)

서지정보

· 발행기관 : 한국화장품미용학회
· 수록지 정보 : 한국화장품미용학회지 / 13권 / 3호 / 501 ~ 508페이지
· 저자명 : 김동옥, 박영아, 조선영, 지홍근

초록

Zein is a water-insoluble plant protein obtained from renewable natural sources and is a promising carrier materials to construct nano sized delivery systems for hydrophobic bioactives. Resveratrol is a polyphenol compound that exists in various plants such as red wine and grape bark, and is known to have anticancer and antioxidant effects as well as skin aging inhibition effects. In this study, a pH driven method without using an organic solvent was used to manufacture resveratrol and zein-lipid composite nanoparticles. Composite nanoparticles (pH 7.0) were formed spontaneously by mixing an alkaline zein solution (pH 12.0) with an acidic glycolipid solution (pH 2.0). We then encapsulated resveratrol inside the particles and studied the possibility of using these nanoparticles to deliver unstable active ingredients into the skin. As the glycolipid content increased, the particle size of zein-to-glycolipid decreased and the zeta potential remained stable above –30 mV. The spherical morphologic construction and relatively small size of formed nanoparticles detected by dynamic light scattering and transmission electron microscopy. Resveratrol was loaded into nanoparticles using a pH transfer method, and FTIR analysis confirmed that the addition of resveratrol did not change the chemical structure of the composite particles. Zein particles loaded with resveratrol exhibited a size of 167.6 ± 52 nm, zeta potential of -34.2 ± 10 mV, suggesting colloidal stability. These results confirmed the possibility of zein as a skin carrier that can exert excellent effects by increasing the stabilization of resveratrol and effectively delivering it into the skin as a new carrier in the cosmetics industry.

영어초록

Zein is a water-insoluble plant protein obtained from renewable natural sources and is a promising carrier materials to construct nano sized delivery systems for hydrophobic bioactives. Resveratrol is a polyphenol compound that exists in various plants such as red wine and grape bark, and is known to have anticancer and antioxidant effects as well as skin aging inhibition effects. In this study, a pH driven method without using an organic solvent was used to manufacture resveratrol and zein-lipid composite nanoparticles. Composite nanoparticles (pH 7.0) were formed spontaneously by mixing an alkaline zein solution (pH 12.0) with an acidic glycolipid solution (pH 2.0). We then encapsulated resveratrol inside the particles and studied the possibility of using these nanoparticles to deliver unstable active ingredients into the skin. As the glycolipid content increased, the particle size of zein-to-glycolipid decreased and the zeta potential remained stable above –30 mV. The spherical morphologic construction and relatively small size of formed nanoparticles detected by dynamic light scattering and transmission electron microscopy. Resveratrol was loaded into nanoparticles using a pH transfer method, and FTIR analysis confirmed that the addition of resveratrol did not change the chemical structure of the composite particles. Zein particles loaded with resveratrol exhibited a size of 167.6 ± 52 nm, zeta potential of -34.2 ± 10 mV, suggesting colloidal stability. These results confirmed the possibility of zein as a skin carrier that can exert excellent effects by increasing the stabilization of resveratrol and effectively delivering it into the skin as a new carrier in the cosmetics industry.

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