프란루카스트와 폴리(N-비닐피롤리돈)의 나노고체분산체에 의한 용출률 개선 (Improvement of Dissolution Property of Pranlukast by Nano-Solid Dispersion with Poly(N-vinylpyrrolidone))

서지정보

· 발행기관 : 한국조직공학과 재생의학회
· 수록지 정보 : 조직공학과 재생의학 / 5권 / 4호 / 600 ~ 605페이지
· 저자명 : 박상욱, 이준희, 김대성, 김원, 박종학, 안식일, 김윤태, 신형식, 이종문, 강길선

초록

To overcome solubility of poorly water soluble drugs, we prepared solid dispersions containing nanoparticles of water insoluble pranlukast using spray dryer. These solid dispersions formulated to improve the dissolution of pranlukast. PVP-K30 used as a water soluble carrier for the solid dispersion and poloxamer used as a surfactant. Characterization of pranlukast solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and particle size analyzer. SEM and DSC were found that pranlukast is amorphous in solid dispersions. Particle size analyzer was used to investigate size of pranlukast in solid dispersions. The in vitro dissolution rate of pranlukast solid dispersion was significantly higher than the conventional drugs(Onon® and Prakanon®), as 11~33 folds. This studies illustrated the potential use of solid dispersion for the delivery of poorly water soluble drug, such as pranlukast by the oral route.

영어초록

To overcome solubility of poorly water soluble drugs, we prepared solid dispersions containing nanoparticles of water insoluble pranlukast using spray dryer. These solid dispersions formulated to improve the dissolution of pranlukast. PVP-K30 used as a water soluble carrier for the solid dispersion and poloxamer used as a surfactant. Characterization of pranlukast solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and particle size analyzer. SEM and DSC were found that pranlukast is amorphous in solid dispersions. Particle size analyzer was used to investigate size of pranlukast in solid dispersions. The in vitro dissolution rate of pranlukast solid dispersion was significantly higher than the conventional drugs(Onon® and Prakanon®), as 11~33 folds. This studies illustrated the potential use of solid dispersion for the delivery of poorly water soluble drug, such as pranlukast by the oral route.

참고자료

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