경구 비스포스포네이트 장기 투여 이후 발생한 턱뼈 골괴사 환자 1예 − 증례 보고 − (Oral Bisphosphonate Related Osteonecrosis of the Jaws −A case report−)

서지정보

· 발행기관 : 대한재활의학회
· 수록지 정보 : Annals of Rehabilitation Medicine / 34권 / 5호 / 599 ~ 602페이지
· 저자명 : 정점순, 이주강

초록

Bisphosphonates are the most widely prescribed medications for the treatment of osteoporosis. However, bisphosphonate- related osteonecrosis of the jaw (BRONJ) is recently recognized as a serious complication among patients receiving bisphosphonate therapy. Most reports relate to BRONJ result from intravenous bisphosphonate or dental procedure. We report a case of mandible osteonecrosis related with oral bisphosphonate medication. A-63-year old woman suffered from toothache, cheek swelling and heating sense visited our dental clinic. She had taken oral alendronate and antihypertensive agents for 4 years because of osteoporosis and hypertension. Dental physical examination, radiologic study and pathologic study showed the severe inflammation and osteonecrosis of the mandible. Therefore we diagnosed the patient as having BRONJ and she stopped to take bisphosphonate and received surgical treatment with bone curettage. After surgical treatment and stopping bisphosphonate, her symptoms were improved. (J Korean Acad Rehab Med 2010; 34: 599-602)

영어초록

Bisphosphonates are the most widely prescribed medications for the treatment of osteoporosis. However, bisphosphonate- related osteonecrosis of the jaw (BRONJ) is recently recognized as a serious complication among patients receiving bisphosphonate therapy. Most reports relate to BRONJ result from intravenous bisphosphonate or dental procedure. We report a case of mandible osteonecrosis related with oral bisphosphonate medication. A-63-year old woman suffered from toothache, cheek swelling and heating sense visited our dental clinic. She had taken oral alendronate and antihypertensive agents for 4 years because of osteoporosis and hypertension. Dental physical examination, radiologic study and pathologic study showed the severe inflammation and osteonecrosis of the mandible. Therefore we diagnosed the patient as having BRONJ and she stopped to take bisphosphonate and received surgical treatment with bone curettage. After surgical treatment and stopping bisphosphonate, her symptoms were improved. (J Korean Acad Rehab Med 2010; 34: 599-602)

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