Current status of genomic prediction using Multi-omics data in livestock

서지정보

· 발행기관 : 충북대학교 동물의학연구소
· 수록지 정보 : Journal of Biomedical and Translational Research / 18권 / 4호
· 저자명 : Na-Rae An, Seung-Su Lee, Jong-Eun Park, Han-Ha Chai, Yong-Min Cho, Dajeong Lim

목차

Introduction
Materials and Methods
멀티 오믹스 정보를 활용한 유전체 예측
유전체예측에 활용되는 멀티 오믹스 자료의 특성
멀티 오믹스 정보를 활용한 유전체 예측 연구 현황
멀티 오믹스 기반 유전체 예측 활용 방안
Conclusion
Acknowledgements
References

영어초록

It became possible to perform genomic predictions using single nucleotide polymorphism (SNP) with advancements in genomics technology, not only in human but in livestock as well. There are strong interests in improving economical traits in livestock through identifying causative mutation, genes or predicting genomic breeding values. We present the current status of genome prediction studies for phenotype estimation of economic traits in livestock from various perspectives based on the genomic area. First, we introduce theoretical background of genomic prediction methods and newest development on SNP information. Thanks to develop sequencing technology, multi-omics data can be used to predict phenotypes associated with the economic traits. In particular, many studies show that genomic prediction accuracy of genomic partitioning data based on the biological information is higher than that of commercial SNP chip. Therefore, multi-omics data can be useful for genomic prediction studies. It is also important that researchers should consider factors affecting genomic prediction accuracy such as heritability, Quantitative Trait Loci (QTL) and marker density, size and structure of reference population. We also introduce genomic prediction studies based on the integration of multi-omics data that shows improvement of prediction accuracy than typical Genomic Best Linear Unbiased Prediction (GBLUP) models. We concluded that genomic prediction studies can be expanded to apply social issues, new phenotypes, or precision agriculture such as diseases, climate change, and metabolism including economic traits with multi-omics data using high-throughput technologies.

참고자료

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